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These are defined as the diseases which arise when the body’s Immune system’s response in a destructive manner against self tissue. Auto-Immune disorders are mainly the result of overactivity of the immune system, in which the Immune system attacks and damages the body's own healthy cells. Auto-Immune disorders mainly occur due to failure of “Immunological intolerance” (a process by which the Immune system recognizes and accepts self tissues).


Auto-Immune disorders are more common in women than men due the following factors, these are:

Genetic Variations - Genes like HLA gene (that results most of the Auto-Immune diseases), Gene like PTPN22 (that results Rheumatoid arthritis and Type-1 Diabetes), Gene like ATG5 (that results in systemic lupus erythematosus) etc.

Smoking - Cigarette smokers are more prone to develop Auto-Immune diseases.

Infections - Some infections like acute rheumatic fever followed by Streptococcal infection may lead to occurrence of Auto-Immune disorders.

Side Effects of Drug - Occasionally these may develop after the counter bad effects of some drugs (e.g. - anesthetic agent Halothane).


Auto-Immune disorders are of two main types, these are:

ORGAN – specific autoimmune disorders - following are the examples of organ-specific autoimmune disorders:

  • Coeliac Disease
  • Grave’s Disease
  • Addison’s Disease
  • Hashimoto’s Thyroiditis
  • Psoriasis
  • Vitiligo
  • Autoimmune Haemolytic Aanaemia
  • Pernicious Anaemia
  • Rheumatoid Arthritis
  • Multiple Sclerosis

MULTI-SYSTEM AUTOIMMUNE DISORDERS - Following are some types of multi- system autoimmune disorders:

  • Systemic Lupus Erythematosus
  • Mixed Connective Tissue Disease
  • Systemic Sclerosis


RHEUMATOID ARTHRITIS - RA is an autoimmune chronic inflammatory disorder that can affect the joints as well as a wide variety of body systems, including the skin, eyes, lungs, heart & blood vessels; it affects the lining of joints that eventually results in bone erosion & joint deformity. It causes Tender, warm & swollen joints, joint stiffness that is usually worse in the mornings, and after inactivity, general fatigue, Fever and sometimes weight loss.

MULTIPLE SCLEROSIS - Multiple sclerosis is an auto-immune disorder in which the immune system attacks the protective sheath (myelin) that covers nerve fibers & causes problem in communication between brain & rest of the body; Multiple sclerosis can cause permanent deterioration of the nerves; it is a potentially disabling disease of central nervous system which mainly affects the movement of the body.

PSORIASIS - Psoriasis is a chronic inflammatory, hyper-proliferative autoimmune skin disorder which causes skin cells to multiply up to 10 times faster than normal. It is characterized by well-defined, erythematous scaly plaques, particularly affects the extensor surfaces & scalp or can grow anywhere in the body. It cannot pass from one person to another; the disease usually follows a remitting & relapsing course. In severe cases, psoriasis can cover large parts of the body.

SLE (SYSTEMIC LUPUS ERYTHEMATOSUS) - SLE is an auto-immune disorder in which the immune system attacks its own tissues especially the connective tissues resulting in inflammation & tissue damage in the affected organs; It usually affect the joints, skin, brain, lungs, kidneys & blood; The disease can be mild or life-threatening.

COELIAC DISEASE – It is a chronic digestive autoimmune disorder resulting from an immune reaction after eating Gluten (a specific protein found in Wheat, Barley, Rye and sometimes Oats.